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體內抗體——小鼠免疫細胞特異性耗竭抗體

來源: 發布時間:2025-03-14

In vivo antibodies——Mouse Immune Cell Specific Depletion Antibodies

In vivo Cell Specific

Depletion – T Cell, B Cell, NK Cells, and More

Mouse

Immune Cell Specific Depletion Antibodies | Leinco


Leinco

Technologies offers monoclonal antibodies to mouse cell specific surface

proteins and cytokines for in vivo cell specific depletion studies.  Depletion can occur naturally (i.e. in HIV)

or be induced for treatment purposes. Therefore, it is a useful tool in

therapeutic, immunotherapy and diagnostic research. It is common practice for

researchers to use antibodies to remove a specific cell type to infer its

function, and mouse cell depletion in vivo experiments are used to establish

the role of specific cell types in a variety of immunological processes. As an

example, in vivo T cell depletion experiments using a combination of anti-CD4

(Clone GK1.5) and anti-CD8 (Clone 2.43 or 53-5.8) antibodies are efficient and

produce less deleterious effects on other blood cell populations compared to

using CD3 depletion antibodies (like clone 145-2C11 or 17A2) . Many of these

antibodies have been developed by academic and government labs all over the

world and have been reported and referenced for use in in vivo studies to

deplete a specific cell type (See the List below organized by clone and cell

type for depletion). Check out each clone’s datasheet for specific literature

references and information on dosage and product use.


Cell-Specific Depletion Antibodies from Leinco Technologies

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